Seth & the gang
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Unique properties among signaling molecules

  • 7 distinct signals


Differential phosphorylation at the 3, 4, and 5 position on the inositol ring allows for the generation of seven distinct phosphoinositides. All seven are found naturally occurring in the cell membranes of all higher eukaryotes.


  • Rapidly interconverted


Phosphoinositide kinases and phosphatases can rapidly convert one specific phosphoinositide into another.


  • Source of other classes of signaling molecules


Inositol trisphosphate (IP3), diacylglycerol, and phosphatidic acid are among the signaling molecules that can be produced from phosphoinositides


  • Membrane-bound/Well-suited to spatially restricted signaling


The lipid tail renders the phosphoinositides obligately membrane-bound. This makes them well-suited to mark particular membrane compartments, or subdomains within a membrane.

Seth Field's Lab


Studying Phosphoinositides at UCSD


2005-2014 Seth Field

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