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Farber-Katz SE, Dippold HC, Buschman MD, Peterman MC, Xing M, Noakes CJ, Tat J, Ng MM, Rahajeng J, Cowan DM, Fuchs GJ, Zhou H, Field SJ.
DNA Damage Triggers Golgi Dispersal via DNA-PK and GOLPH3.
Cell 2014; 156:413-27.
Pubmed Movies

see also

Ng MM, Dippold HC, Buschman MD, Noakes CJ, Field SJ.
GOLPH3L antagonizes GOLPH3 to determine Golgi morphology.
Molecular Biology of the Cell 2013; 24:796-808.
Pubmed PDF

Murray MJ, Ng MM, Fraval H, Tan J, Liu W, Smallhorn M, Brill JA, Field SJ, Saint R.
Regulation of Drosophila mesoderm migration by phosphoinositides and the PH domain of the Rho GTP Exchange Factor Pebble.
Developmental Biology 2012; 372:17-27.
Pubmed

Bishé B, Syed GH, Field SJ, Siddiqui A.
Role of Phosphatidylinositol-4-Phosphate (PI4P) and Its Binding Protein GOLPH3 in Hepatitis C Virus Secretion.
J Biol Chem 2012; 287:27637-47.
Pubmed

Schmid MC, Avraamides CJ, Dippold HC, Franco I, Foubert P, Ellies LG, Acevedo LM, Manglicmot JR, Song X, Wrasidlo W, Blair SL, Ginsberg MH, Cheresh DA, Hirsch E, Field SJ, Varner JA.
Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3Kgamma, a single convergent point promoting tumor inflammation and progression.
Cancer Cell 2011; 19:715-27.
Pubmed

see also

  • Minireview: Beagle B, Fruman DA.. A lipid kinase cousin cooperates to promote cancer. Cancer Cell 2011; 19:693-5. Pubmed

IIglesias-Ara A, Zenarruzabeitia O, Fernandez-Rueda J, Sanchez-Tillo E, Field SJ, Celada A, Zubiaga AM.
Accelerated DNA Replication in E2F1- and E2F2-deficient Macrophages Leads to Induction of DNA Damage Response and p21CIP1-dependent Senescence.
Oncogene; 2010; 29:5579-90.
Pubmed

Nhek S, Ngo M, Yang X, Ng MM, Field SJ, Asara JM, Ridgway ND, Toker A.
Regulation of OSBP Golgi Localization through Protein Kinase D-mediated Phosphorylation.
Molecular Biology of the Cell 2010; 21:2327-37.
Pubmed

Dippold HC, Ng MM*, Farber-Katz SE*, Lee SK, Kerr ML, Peterman M, Sim R, Wiharto P, Galbraith KA, Madhavarapu S, Fuchs GJ, Meerloo T, Farquhar MG, Zhou H, Field SJ.
GOLPH3 Bridges Phosphatidylinositol-4-Phosphate and Actomyosin to Stretch and Shape the Golgi to Promote Budding.
Cell 2009; 139:337-351. *these authors contributed equally
Pubmed PDF Suppl Movies

see also

Bielas SL, Silhavy JL, Brancati F, Kisseleva MV, Al-Gazali L, Sztriha L, Bayoumi RA, Zaki MS, Abdel-Aleem A, Rosti O, Kayserili H, Swistun D, Scott LC, Bertini E, Boltshauser E, Fazzi E, Travaglini L,
Field SJ, Gayral S, Jacoby M, Schurmans S, Dallapiccola B, Majerus PW, Valente EM, Gleeson JG.
Mutations in the inositol polyphosphate-5-phosphatase E gene link phosphatidyl inositol signaling to the ciliopathies.
Nature Genetics 2009; 41:1032-6.
Pubmed PDF Suppl

Infante A, Laresgoiti U, Fernández-Rueda J, Fullaondo A, Galán J, Díaz-Uriarte R, Malumbres M, Field SJ, Zubiaga AM.
E2F2 represses cell cycle regulators to maintain quiescence.
Cell Cycle. 2008; 7:3915-27.
Pubmed PDF Suppl

Yang X, Ongusaha PP, Miles PD, Havstad JC, Zhang F, So WV, Kudlow JE, Michell RH, Olefsky JM, Field SJ, Evans RM.
Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance.
Nature. 2008 Feb 21;451(7181):964-9.
Pubmed PDF Suppl Movies

see also Faculty of 1000 Biology

Field SJ.
PIP3 produced in response to stimulation by a growth factor.
ASCB Image & Video Library. 2007 Aug;VID-28.
Vid

Chang JD, Sukhova GK, Libby P, Schvartz E, Lichtenstein AH, Field SJ, Kennedy C, Madhavarapu S, Luo J, Wu D, Cantley LC.
Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis.
Proc Natl Acad Sci U S A. 2007 May 8;104(19):8077-82. Epub 2007 May 2.
Pubmed PDF

Gozani O, Field SJ, Ferguson CG, Ewalt M, Mahlke C, Cantley LC, Prestwich GD, Yuan J.
Modification of protein sub-nuclear localization by synthetic phosphoinositides: Evidence for nuclear phosphoinositide signaling mechanisms.
Adv Enzyme Regul. 2005;45:171-85.
Pubmed

Field SJ, Madson N, Kerr ML, Galbraith KA, Kennedy CE, Tahiliani M, Wilkins A, Cantley LC.
PtdIns(4,5)P2 functions at the cleavage furrow during cytokinesis.
Current Biology. 2005 Aug 9;15(15):1407-1412.
Pubmed PDF Suppl Movies

see also

Luo J, Field SJ, Lee JY, Cantley LC.
The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex.
J Cell Biol. 2005 Aug 1;170(3):455-64. Epub 2005 Jul 25.
Pubmed PDF

Yuan H, Luo J, Field S, Weissleder R, Cantley L, Josephson L.
Synthesis and activity of C11-modified wortmannin probes for PI3 kinase.
Bioconjug Chem. 2005 May-Jun;16(3):669-75.
Pubmed PDF

Mitra P, Zhang Y, Rameh LE, Ivshina MP, McCollum D, Nunnari JJ, Hendricks GM, Kerr ML, Field SJ, Cantley LC, Ross AH.
A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast.
J Cell Biol. 2004 Jul 19;166(2):205-11. Epub 2004 Jul 12.
Pubmed PDF

Chang JD, Field SJ, Rameh LE, Carpenter CL, Cantley LC.
Identification and characterization of a phosphoinositide phosphate kinase homolog.
J Biol Chem. 2004 Mar 19;279(12):11672-9. Epub 2003 Dec 30.
Pubmed PDF

Gozani O, Karuman P, Jones DR, Ivanov D, Cha J, Lugovskoy AA, Baird CL, Zhu H, Field SJ, Lessnick SL, Villasenor J, Mehrotra B, Chen J, Rao VR, Brugge JS, Ferguson CG, Payrastre B, Myszka DG, Cantley LC, Wagner G, Divecha N, Prestwich GD, Yuan J.
The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor.
Cell. 2003 Jul 11;114(1):99-111.
Pubmed PDF

Field SJ, Lamia KA, Rameh LE, Cantley LC.
Lipid research picks up speed on the slopes of Taos.
Dev Cell. 2002 Apr;2(4):407-10.
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Field SJ*, Kanai F,* Liu H*, Akbary H*, Matsuo T, Brown GE, Cantley LC, Yaffe MB.
The PX domains of p47phox and p40phox bind to lipid products of PI(3)K.
Nat Cell Biol. 2001 Jul;3(7):675-8. *these authors contributed equally
Pubmed PDF

see also

  • Minireview: Wishart MJ, Taylor GS, Dixon JE. Phoxy lipids: revealing PX domains as phosphoinositide binding molecules. Cell. 2001 Jun 29;105(7):817-20. Pubmed
  • Faculty of 1000 Biology

Iglesias A, Murga M, Laresgoiti U, Skoudy A, Bernales I, Fullaondo A, Moreno B, Lloreta J, Field SJ, Real FX, Zubiaga AM.
Diabetes and exocrine pancreatic insufficiency in E2F1/E2F2 double-mutant mice.
J Clin Invest. 2004 May;113(10):1398-407.
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Murga M, Fernandez-Capetillo O, Field SJ, Moreno B, Borlado LR, Fujiwara Y, Balomenos D, Vicario A, Carrera AC, Orkin SH, Greenberg ME, Zubiaga AM.
Mutation of E2F2 in mice causes enhanced T lymphocyte proliferation, leading to the development of autoimmunity.
Immunity. 2001 Dec;15(6):959-70.
Pubmed PDF

Wu L, Timmers C, Maiti B, Saavedra HI, Sang L, Chong GT, Nuckolls F, Giangrande P, Wright FA, Field SJ, Greenberg ME, Orkin S, Nevins JR, Robinson ML, Leone G.
The E2F1-3 transcription factors are essential for cellular proliferation.
Nature. 2001 Nov 22;414(6862):457-62.
Pubmed PDF

Zhu JW, Field SJ, Gore L, Thompson M, Yang H, Fujiwara Y, Cardiff RD, Greenberg M, Orkin SH, DeGregori J.
E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis.
Mol Cell Biol. 2001 Dec;21(24):8547-64.
Pubmed PDF

Leone G, Sears R, Huang E, Rempel R, Nuckolls F, Park CH, Giangrande P, Wu L, Saavedra HI, Field SJ, Thompson MA, Yang H, Fujiwara Y, Greenberg ME, Orkin S, Smith C, Nevins JR.
Myc requires distinct E2F activities to induce S phase and apoptosis.
Mol Cell. 2001 Jul;8(1):105-13.
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Garcia I, Murga M, Vicario A, Field SJ, Zubiaga AM.
A role for E2F1 in the induction of apoptosis during thymic negative selection.
Cell Growth Differ. 2000 Feb;11(2):91-8.
Pubmed PDF

Field SJ, Tsai FY, Kuo F, Zubiaga AM, Kaelin WG Jr, Livingston DM, Orkin SH, Greenberg ME.
E2F-1 functions in mice to promote apoptosis and suppress proliferation.
Cell. 1996 May 17;85(4):549-61.
Pubmed PDF

see also the Minireview: Weinberg RA. E2F and cell proliferation: a world turned upside down. Cell. 1996 May 17;85(4):457-9. Pubmed

Field SJ.
Multiplexed minipreps for rapid screening of large numbers of recombinant DNA clones.
Biotechniques. 1993 Apr;14(4):530-2.
Pubmed PDF

Field SJ, Johnson RS, Mortensen RM, Papaioannou VE, Spiegelman BM, Greenberg ME.
Growth and differentiation of embryonic stem cells that lack an intact c-fos gene.
Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):9306-10.
Pubmed PDF

Bourguignon LY, Field S, Bourguignon GJ.
Phosphorylation of a tropomyosin-like (30 KD) protein during platelet activation.
J Cell Biochem. 1985;29(1):19-30.
Pubmed PDF

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Studying Phosphoinositides at UCSD

 

© 2005-2014 Seth Field

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