Our publications

Yang X, Ongusaha PP, Miles PD, Havstad JC, Zhang F, So WV, Kudlow JE, Michell RH, Olefsky JM, Field SJ, Evans RM. Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance. Nature. 2008 Feb 21;451(7181):964-9. Abstract PDF Suppl Movies

Field SJ. PIP3 produced in response to stimulation by a growth factor. ASCB Image & Video Library. 2007 Aug;VID-28. Vid

Chang JD, Sukhova GK, Libby P, Schvartz E, Lichtenstein AH, Field SJ, Kennedy C, Madhavarapu S, Luo J, Wu D, Cantley LC. Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis. Proc Natl Acad Sci U S A. 2007 May 8;104(19):8077-82. Epub 2007 May 2. Abstract PDF

Gozani O, Field SJ, Ferguson CG, Ewalt M, Mahlke C, Cantley LC, Prestwich GD, Yuan J. Modification of protein sub-nuclear localization by synthetic phosphoinositides: Evidence for nuclear phosphoinositide signaling mechanisms. Adv Enzyme Regul. 2005 Sep 29 [Epub ahead of print]. Abstract

Field SJ, Madson N, Kerr ML, Galbraith KA, Kennedy CE, Tahiliani M, Wilkins A, Cantley LC. PtdIns(4,5)P2 functions at the cleavage furrow during cytokinesis. Current Biology. 2005 Aug 9;15(15):1407-1412. Abstract PDF Suppl Movies

see also the Research Highlight: Nature. 2005 Aug 18;436(7053):892.

and the Review: Janetopouos, C., Devreotes, P. Phosphoinositide signaling plays a key role in cytokinesis. J Cell Biol. 2006 Aug 14; 174(4). Abstract

Luo J, Field SJ, Lee JY, Cantley LC. The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex. J Cell Biol. 2005 Aug 1;170(3):455-64. Epub 2005 Jul 25. Abstract PDF

Yuan H, Luo J, Field S, Weissleder R, Cantley L, Josephson L. Synthesis and activity of C11-modified wortmannin probes for PI3 kinase. Bioconjug Chem. 2005 May-Jun;16(3):669-75. Abstract PDF

Mitra P, Zhang Y, Rameh LE, Ivshina MP, McCollum D, Nunnari JJ, Hendricks GM, Kerr ML, Field SJ, Cantley LC, Ross AH. A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast. J Cell Biol. 2004 Jul 19;166(2):205-11. Epub 2004 Jul 12. Abstract PDF

Chang JD, Field SJ, Rameh LE, Carpenter CL, Cantley LC. Identification and characterization of a phosphoinositide phosphate kinase homolog. J Biol Chem. 2004 Mar 19;279(12):11672-9. Epub 2003 Dec 30. Abstract PDF

Gozani O, Karuman P, Jones DR, Ivanov D, Cha J, Lugovskoy AA, Baird CL, Zhu H, Field SJ, Lessnick SL, Villasenor J, Mehrotra B, Chen J, Rao VR, Brugge JS, Ferguson CG, Payrastre B, Myszka DG, Cantley LC, Wagner G, Divecha N, Prestwich GD, Yuan J. The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell. 2003 Jul 11;114(1):99-111. Abstract PDF

Field SJ, Lamia KA, Rameh LE, Cantley LC. Lipid research picks up speed on the slopes of Taos. Dev Cell. 2002 Apr;2(4):407-10. Abstract PDF

Field SJ*, Kanai F,* Liu H*, Akbary H*, Matsuo T, Brown GE, Cantley LC, Yaffe MB. The PX domains of p47phox and p40phox bind to lipid products of PI(3)K. Nat Cell Biol. 2001 Jul;3(7):675-8. *these authors contributed equally Abstract PDF

see also the Minireview: Wishart MJ, Taylor GS, Dixon JE. Phoxy lipids: revealing PX domains as phosphoinositide binding molecules. Cell. 2001 Jun 29;105(7):817-20. Abstract

Iglesias A, Murga M, Laresgoiti U, Skoudy A, Bernales I, Fullaondo A, Moreno B, Lloreta J, Field SJ, Real FX, Zubiaga AM. Diabetes and exocrine pancreatic insufficiency in E2F1/E2F2 double-mutant mice. J Clin Invest. 2004 May;113(10):1398-407. Abstract PDF

Murga M, Fernandez-Capetillo O, Field SJ, Moreno B, Borlado LR, Fujiwara Y, Balomenos D, Vicario A, Carrera AC, Orkin SH, Greenberg ME, Zubiaga AM. Mutation of E2F2 in mice causes enhanced T lymphocyte proliferation, leading to the development of autoimmunity. Immunity. 2001 Dec;15(6):959-70. Abstract PDF

Wu L, Timmers C, Maiti B, Saavedra HI, Sang L, Chong GT, Nuckolls F, Giangrande P, Wright FA, Field SJ, Greenberg ME, Orkin S, Nevins JR, Robinson ML, Leone G. The E2F1-3 transcription factors are essential for cellular proliferation. Nature. 2001 Nov 22;414(6862):457-62. Abstract PDF

Zhu JW, Field SJ, Gore L, Thompson M, Yang H, Fujiwara Y, Cardiff RD, Greenberg M, Orkin SH, DeGregori J. E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis. Mol Cell Biol. 2001 Dec;21(24):8547-64. Abstract PDF

Leone G, Sears R, Huang E, Rempel R, Nuckolls F, Park CH, Giangrande P, Wu L, Saavedra HI, Field SJ, Thompson MA, Yang H, Fujiwara Y, Greenberg ME, Orkin S, Smith C, Nevins JR. Myc requires distinct E2F activities to induce S phase and apoptosis. Mol Cell. 2001 Jul;8(1):105-13. Abstract PDF

Garcia I, Murga M, Vicario A, Field SJ, Zubiaga AM. A role for E2F1 in the induction of apoptosis during thymic negative selection. Cell Growth Differ. 2000 Feb;11(2):91-8. Abstract PDF

Field SJ, Tsai FY, Kuo F, Zubiaga AM, Kaelin WG Jr, Livingston DM, Orkin SH, Greenberg ME. E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell. 1996 May 17;85(4):549-61. Abstract PDF

see also the Minireview: Weinberg RA. E2F and cell proliferation: a world turned upside down. Cell. 1996 May 17;85(4):457-9. Abstract

Field SJ. Multiplexed minipreps for rapid screening of large numbers of recombinant DNA clones. Biotechniques. 1993 Apr;14(4):530-2. Abstract PDF

Field SJ, Johnson RS, Mortensen RM, Papaioannou VE, Spiegelman BM, Greenberg ME. Growth and differentiation of embryonic stem cells that lack an intact c-fos gene. Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):9306-10. Abstract PDF

Bourguignon LY, Field S, Bourguignon GJ. Phosphorylation of a tropomyosin-like (30 KD) protein during platelet activation. J Cell Biochem. 1985;29(1):19-30. Abstract PDF