Unique properties among signaling molecules
Differential phosphorylation at the 3, 4, and 5 position on the inositol ring allows for the generation of seven distinct phosphoinositides. All seven are found naturally occurring in the cell membranes of all higher eukaryotes.
Phosphoinositide kinases and phosphatases can rapidly convert one specific phosphoinositide into another.
Inositol trisphosphate (IP3), diacylglycerol, and phosphatidic acid are among the signaling molecules that can be produced from phosphoinositides
The lipid tail renders the phosphoinositides obligately membrane-bound. This makes them well-suited to mark particular membrane compartments, or subdomains within a membrane.
Seth Field's Lab
Studying Phosphoinositides at UCSD
© 2005-2014 Seth Field