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Phosphoinositides

Unique properties among signaling molecules

  • 7 distinct signals

 

Differential phosphorylation at the 3, 4, and 5 position on the inositol ring allows for the generation of seven distinct phosphoinositides. All seven are found naturally occurring in the cell membranes of all higher eukaryotes.

 

  • Rapidly interconverted

 

Phosphoinositide kinases and phosphatases can rapidly convert one specific phosphoinositide into another.

 

  • Source of other classes of signaling molecules

 

Inositol trisphosphate (IP3), diacylglycerol, and phosphatidic acid are among the signaling molecules that can be produced from phosphoinositides

 

  • Membrane-bound/Well-suited to spatially restricted signaling

 

The lipid tail renders the phosphoinositides obligately membrane-bound. This makes them well-suited to mark particular membrane compartments, or subdomains within a membrane.

Seth Field's Lab

 

Studying Phosphoinositides at UCSD

 

2005-2014 Seth Field

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